|
KMID : 0366220050400020129
|
|
Korean Journal of Hematology
2005 Volume.40 No. 2 p.129 ~ p.132
|
|
|
Aggressive Systemic Mastocytosis Following Ovarian Germ Cell Tumor
|
|
Huh Eun-Ju
Park So-Young
Choi Sang-Rhim
Chung Seung-Yun
Kang Jin-Han
Kim Kyoung-Mee
Lee Je-Hoon
Jeong Chang-Mo
|
|
|
Abstract
|
|
|
|
A 4 years-old girl was diagnosed aggressive systemic mastocytosis on 2 months later after end of chemotherapy, including cisplatin, bleomycin, and etoposide, for ovarian germ cell tumor (GCT). She was shown pigmented skin lesion, hepatosplenomegaly, thrombocytopenia, and increased mast cells with positive toluidine blue staining in bone marrow examination. The immunohistochemical stain for c-kit is highly expressed in bone marrow and skin, but not in GCT specimen. However, c-kit point mutation is detected in bone marrow, peripheral blood, and GCT tissue from product of PCR by oligonucleotide sequencing. We report one case of aggressive systemic mastocytosis following ovarian germ cell tumor with c-kit point mutation.
|
|
|
KEYWORD
|
|
|
Germ cell tumor, Aggressive systemic mastocytosis, c-kit point mutation
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|
|